Synthesis and Biological Activity of Copper(Ii) Schiff Base Complexes as Potential Agents for Tuberculosis Therapy

Abstract

Four new copper (II) Schiff base complexes (CuL1-CuL4) were synthesized by reaction of CuCl 2 .2H 2 O with Schiff bases L1-L4 derived from condensation of 2-aminopyridine with substituted saliclyaldehydes. The compounds were characterized by elemental analysis, infrared (IR), nuclear magnetic resonance (NMR), electronic absorption and molar conductivity. The Schiff bases reacted as bidentate ligands towards copper (II) to yield complexes with a 1:1 (M:L) molar ratio. Evaluation of the in-vitro anti-tuberculosis activity against mycobacterium tuberculosis H 37 RV using the proportion method showed the complexes exhibited enhanced in- vitro anti-tuberculosis activity against the bacteria compared to the free ligands and reference compound (INH).