Synthesis and in-vitro antibacterial study of some Schiff base copper(II) complexes derived from 4-phenylsemicarbazone

Abstract

Six new Schiff base ligands derived from the condensation of 5-substituted 2-hydroxybenzaldehyde with 4- phenylsemicarbazide (HL1-HL6) and their copper(II) complexes were synthesized and characterized using melting point, 1 H NMR and Infrared (IR). IR data confirmed that the ligands coordinated to the metal ion in a bidentate manner through the azomethine nitrogen and carbonyl oxygen resulting in metal complexes with a 1:2 metal :ligand ratio. The Schiff bases and copper complexes exhibited good in-vitro antibacterial activity against S.aureus and E.coli in ethyl acetate with zones of inhibition ranging from 9 -27 mm indicating their potential as good broad spectrum antibacterial agents.