Evaluation of Mectizan Efficacy in the Treatment of Onchocerciasis using Microfilarial load in a community in South-Eastern Nigeria

Abstract

Studies on the evaluation of mectizan efficacy in the treatment of onchocerciasis using microfilarial load in Aninegeye community, South Eastern Nigeria was carried out.  Before the commencement of mectizan administration, 50% prevalence of Onchocerciasis was reported for this community. After several years of administration of mectizan of 200 individuals examined in Aninegeye community, 3 (1.50%) prevalence was reported.  There was no significant difference between the male and female individuals (P < 0.05).  This research confirmed mectizan to be a highly effective microfilaricide. Continuous administration of this drug with completely eliminate this infection in this community and in other communities in the South-Eastern Nigeria where prevalence is still reported.