Evaluation of the Activities of G6PDH and LDH in the Liver of Adult Wistar Rats following the administration of Ocimum sanctum

Abstract

The aim of this study was to investigate some of the effects of aqueous extract of Ocimum sanctum on glucose-6-phosphate dehydrogenase and lactate dehydrogenase in adult wistar rats (Rattus norvergicus). Thirty two adult wistar rats weighing between 150-230g used in this experiment were divided into four groups of eight (n=8) animals each. Each animal in Group I, II, III and control were administered respectively with 250mg/kg bw, 150mg/kg bw, 50mg/kg bw and 0 kg bw of the extract per day for a period of three weeks (21 days) through the oral route. At the end of this investigation, a dose-dependent increased activity of the enzymes were observed. . This observations affirms the earlier observed hepato-protective effect of ocimum sanctum. This experiment also suggests that carbohydrates are facilitated more along the hexose monophosphate pathway for G6PDH and the generation of lactate may serve as substrate for gluconeogenesis.