Major Risk Factors In HPV DNA Detection in Unisex Immunosuppressed Cohorts

Abstract

Risk factors in HPV/HIV co-infectivity were considered in unisex cohorts aged 16 years and above. It was a completely randomized sample collection research design; with informed consent research questionnaires administered to the subjects whose HPV and HIV status had been previously established at the earlier parts of the work. The study was conducted in FCT Abuja in Nigeria. Multivariate odd ratios (ORs) and 95% confidence intervals (CI) for each endpoint were obtained for risk factors after adjustment for confounding variables in their personal data which showed that the ORs - of medical history of Herpes simplex infection in the female and male cohorts were respectively 2.22 (95% CI=1.44-3.64) and 1.4 (95% CI =0.61-3.42): Oral contraceptives usage in the female cohorts was 3.0 (95% CI = 1.10-7.22) : Multiple sexual partners in the female and male cohorts were respectively 2.1 (95% CI = 0.41-9.42) and 2.8 (95% CI = 0.91-8.58). Cigarette smoking, following the same trend were respectively 2.10 (95% CI =0.60-6.81) and 8.0(95% CI =1.36-47.7) ; while Nulliparity in the female cohorts had 3.01 (95% CI =1.59-5.55) . Most sexually active age range of >25 -34< years in the female cohorts was 4.40 (95% CI =1.45-12.0) and in the male cohorts was 5.52(95% CI = 1.7-12.0) .Education in the female and male cohorts had ORs of 2.0(95% CI= 1.0-7.80) and 1.99(0.86-4.5) respectively. These risk factors significantly (P<0.05) enhance HPV/HIV co-infectivity in unisex cohorts aged >16 years, awareness campaigns by various health organs of government must be stepped up for effective combat /control.