Effects of Halofantrine on Oestrous Cycle, Ovulation and Microscopic Structure of the Ovary in Cyclic Sprague–Dawley Rats

Abstract

This study was designed to examine the effects of Halofantrine on oestrous cycle, ovulation and microscopic structure of the ovary in female Sprague–Dawley rats.   Thirty virgin cyclic female rats divided into six experimental groups of five rats each were used for the ovulation studies.  The first 3 groups received 24mg/kg of Halofantrine at 1000h, 1400h and 1800h respectively.      Three groups of rats totalling, twenty-four were used for the experimental study on oestrous cycle; while ten rats were used for the effects on the ovary.  Results showed reduction in number of ova produced in rats given 24 mg/kg of the drug and a more significant reduction (P < 0.01) in those that were administered 48 mg/kg body weight.  The effect on oestrous cycle showed a distorted cycle that is reversible and dose–dependent.  No histological abnormality of the ovary was seen when compared with the control group.  Halofantrine could be developed as a female contraceptive in developing countries