Effects of crude aqueous marijuana extract on length of oestrous cycle and ovulation

Abstract

The effects of crude marijuana extract on the length of oestrous cycle and production of ova were studied in female Wistar rats.  Adult regularly cycling rats (120g – 160g) received oral doses of 20mg/kg/d and 75mg/kg/d crude aqueous marijuana extract for a period of 18 days.  Vaginal smears of the animals were observed daily and the number of ova shed at the end of the treatment period evaluated.  Lengthening of the dioestrous and pro-oestrous phases was observed while the oestrous phase was shortened.  There was a significant reduction in the number of ova shed by the crude marijuana – treated groups (P < 0.05).  While it is obvious from these findings that marijuana produces anti-fertility effects, the exact mechanism by which is does so remains to be elucidated.