Effects of aqueous-alcoholic extract of Persea Americana (leaves) on isolated rabbit heart preparation and blood pressure of normotensive rats

Abstract

The aqueous-alcoholic extract of Persea Americana was investigated for its hypotensive activity on anaesthetized normotensive rats and effect on isolated rabbit heart preparations. It was found that the extract exhibited a dose-related hypotensive activity for all the dose levels (0.05 – 200 mg/kg) with a greater duration at higher dose level (200mg/kg). The extract was also found to reduce the force and the rate of contraction of isolated heart preparation, which was also dose-related. These results would justify the popular use of the plant to treat hyptertension.
Key Words: Persea americana; Hypotensive, Anaesthetized; Normotensive