A method of assay for the estimation of sulphadimidine in tablets

Abstract

A simple and rapid titrimetric method (Back Titration) was used in the assay of Sulphadimidine in commercial tablets. The method involves alkaline hydrolysis of Sulphadimidine to form the corresponding acid. This was followed by back titration of the excess alkali using phenolphthalein as indicator. The results of this assay method were compared with those obtained from the official nitrite titration method. Both methods yielded similar results with high percentage recoveries. The proposed method gave results that agree well with the labeled contents.