Comparative Influences of Extracts of Various Parts of Annona muricata (Soursop) on Basal Lipid Profile and Plasma Fatty Acid Synthase in Wistar Rats
Abstract
Annona muricata (Soursop) contains high levels of annonaceous acetogenins and essential oils to which most of its ethnomedicinal benefits are attributed.
This study was carried out to evaluate the effect of extracts of various parts of Annona muricata on the lipid profile and plasma fatty acid synthase (FAS) of adult Wistar rats.
Five groups of Wistar rats (6 rats per group) received Annona muricata extracts at doses of 100, 200, 400, 600 and 800 mg/kg for 28 days via oral gavage. The rats were sacrificed on the 29th day, and body weights and organ weights were obtained. Plasma lipids and plasma FAS were determined using appropriate assay kits as per manufacturer’s protocol.
The fruit pulp and leaf extracts demonstrated brought about marked and significant decreases in plasma FAS activity, when compared to the stem and root bark extracts (p < 0.05). However, only the fruit pulp extract produced significant and dose-dependent anti-atherogenic and hypolipidemic potential, with reductions in total cholesterol : high density cholesterol (TCHL: HDL) and LDL: HDL ratios (5.41 to 4.31, and 1.71 to 0.79, respectively) as doses of the fruit pulp extract were increased, relative to the root bark extract and control groups (p < 0.05).
The fruit pulp and stem-bark extracts demonstrated better anti-lipidemic and anti-cholesterolemic agents in rats than the leaf and root-bark extracts.
Keywords: Annona muricata, Fruit, Stem bark, Leaf, Lipid profile, Fatty acid synthase
This study was carried out to evaluate the effect of extracts of various parts of Annona muricata on the lipid profile and plasma fatty acid synthase (FAS) of adult Wistar rats.
Five groups of Wistar rats (6 rats per group) received Annona muricata extracts at doses of 100, 200, 400, 600 and 800 mg/kg for 28 days via oral gavage. The rats were sacrificed on the 29th day, and body weights and organ weights were obtained. Plasma lipids and plasma FAS were determined using appropriate assay kits as per manufacturer’s protocol.
The fruit pulp and leaf extracts demonstrated brought about marked and significant decreases in plasma FAS activity, when compared to the stem and root bark extracts (p < 0.05). However, only the fruit pulp extract produced significant and dose-dependent anti-atherogenic and hypolipidemic potential, with reductions in total cholesterol : high density cholesterol (TCHL: HDL) and LDL: HDL ratios (5.41 to 4.31, and 1.71 to 0.79, respectively) as doses of the fruit pulp extract were increased, relative to the root bark extract and control groups (p < 0.05).
The fruit pulp and stem-bark extracts demonstrated better anti-lipidemic and anti-cholesterolemic agents in rats than the leaf and root-bark extracts.
Keywords: Annona muricata, Fruit, Stem bark, Leaf, Lipid profile, Fatty acid synthase
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