Histological Evaluation of the Sub-chronic Toxicity of Methanol Extract of Tetracarpidium conophorum (African Walnut) Seeds in Wistar Albino Rats

Abstract

The purpose of this study was to examine the histopathological effect of methanol extract of Tetracarpidium conophorum seeds on the sub chronic toxicity in Wistar rats. Twenty female rats were divided into 4 groups of 5 rats each; the animals were fed rats mash and given water orally ad libitum. Group I (control) was given distilled water only, while rats in group II, III and IV were administered methanol extract of T. conophorum seeds at different concentration of 500, 1000, and 2000 mg/kg body weight for 30 days. The results show that, there was no death observed and no distortions in the architecture of the various organs (Liver, Spleen, Kidney, Heart and Lungs) when administered various doses of the extract, rather the extract was beneficial to the rats by activating lymphoid cells. It could be concluded that the extract may possess immunogenic properties.
Keywords: Toxicity, Tetracarpidium conophorum, Sub chronic toxicity, Histopathological