Effects of ethanolic extract of Rauwolfia vomitoria root bark on serum lipid profile in Wistar rats

Abstract

The quest for save herbal remedy for the management of cardiovascular diseases prompted this investigation and it is aimed at determining the effect of ethanolic extract of Rauwolfia vomitoria root bark on serum lipid profile - a risk factor in the development coronary artery disease (CAD). Twenty four adult Wistar rats of both sexes were randomly selected into four groups. Group I was given normal saline ad libitum while groups II and III were given 500mg/kg body weight and 1000mg/kg body weight  of the extract respectively  once daily for three weeks after which the serum lipid profile was determined using diagnostic kits. The result showed a significant reduction (p<0.05) in weights of the treated animals when compared with the control. The extract at 500mg/kg and 1000mg/kg body weight produced a significant reduction (P<0.05) in serum Triglycerides (TRG), total Cholesterol(CHL) and Low-Density Lipoprotein(LDL) while High-Density Lipoprotein (HDL) was significantly increased. The dose dependent effects of the extract on serum lipid profile is very crucial, at it may reduce the risk of developing CAD. However, users should be advised against excessive application because of the attendant weight reduction effect.