Studies on the degree of enhancement of activity of Amoxycillin by Clavulante at various ratios on some infectious bacteria

Abstract

The study was carried out with the aim of assessing the effect of increasing ratio of amoxicillin with   Augment in against clinical isolates of Staphylococcus aureus, E. coli, Klebsiella spp. Disc diffusion susceptibility test results indicate that 4:1 preparations are more effective against the clinical isolates with mean zone diameter of 23mm, 17.6mm and 16.2mm for S. aureus, E. coli and K. spp respectively, followed by 2:1 with mean zone diameter of 19.4mm, 13.4mm and 11.4mm for S. aureus, E. coli and K. spp respectively, followed by the rest of the preparations i.e. 6:1, 8:1, 10:1. The susceptibility of 4:1 decreases from 80%, 60%, 40% for S. aureus, E. coli and Kleb. Spp. The result of the Statistical analysis indicates that there was a highly significant difference between 4:1 and the rest of the preparations against S. aureus, and E. coli but there was no significant difference between the preparations against Kleb Species.