Antimycotic susceptibility studies on some Candida species isolated among patients attending Aminu Kano Teaching Hosptial, Kano, Nigeria

Abstract

Background: Studied have established the prevalence of Vaginal Candidiasis (Moniliasis) from women attending antenatal care clinic at the Aminu Kano Teaching Hospital Kano. The antimycotic susceptibility profile has not been reported. Objective: To study the antimycotic susceptibility profiles of some Candida species isolated from suspected patients. Materials and Methods: Seventeen isolates of Candida species isolated from vaginal swabs were subjected to Germ Tube Test (GTT) for identification of Candida albicans. Four antifungal drugs were tested against the isolates to determine their Minimum Inhibitory Concentration (MIC) on the isolates using tube dilution method. Results: Miconazole had the least MIC of 0.15 mg against 41.2% of the isolates. The MIC of Ketoconozole was 0.078 against 35.3% of the isolates. Up to 29.40% of the isolates were inhibited by Nystatin and Clotrimazole at MIC of 19.53IU and 0.093mg respectively. Conclusion: Miconazole has more antifungal activity against Candida albicans isolates at the area of study.